Hormonal imbalance in patients with chronic renal failure in the pre-dialysis and dialysis periods (part1)

The review describes the problem of studying progressive changes hormones concentrations (parathyroid hormone, insulin, somatotropin, prolactin) in patients with chronic renal failure on pre-dialysis and dialysis stages. pathogenetic relationships between kidney function deterioration hormone as well their biological effects were evaluated. Parathyroid is considered an uraemic toxin, since its concentration blood begins to increase when glomerular filtration rate decreases below 50 ml/min. All stages disease are accompanied by disorders calcium-phosphorus metabolism. Prolonged excess parathyroid leads bone loss progression secondary hyperparathyroidism that a frequent complication later and, especially, those treatment. elevation insulin level consequence decrease excretion proximal tubules. So, it results half-life prolongation. Long-term therapy eliminates factors reduce degradation extrarenal tissues, which improvement sensitivity. Experimental clinical studies have shown somatotropin can adversely affect kidneys hyperfiltration glomerulosclerosis. risk possible side should be taken into account prescribing recombinant human insulin-like growth factor. prolactin usually increased due reduced clearance secretion. Hyperprolactinemia manifests galactorrhea hypogonadism. Dialysis can’t normalize prolactin. Modern options for treatment endocrine outlined this article. It was found play important role regulating blood. Endocrine one most components syndrome, requires further studies, aimed searching better strategies prevention hormonal imbalance disease.